Beilstein J. Nanotechnol.2022,13, 699–711, doi:10.3762/bjnano.13.62
viruses.
Keywords: angiotensin converting enzyme-2 (ACE2); antiviral peptides; hydrogen bonds; molecular docking; SARS-CoV-2RBD; Introduction
The current pandemic due to coronavirus disease-19 (COVID-19), caused by the novel virus SARS-CoV-2, has over 533 million of confirmed cases and over 6.3 million
, Y489, Q493, G496, T500, and N501 located on the active region of the SARS-CoV-2RBD (Figure 1b, red rectangle) [6]. Therefore, the RBD has been proposed as one of therapeutic targets to block the infection mechanism of SARS-CoV-2. For instance, peptide analogues of the ACE2 receptor (I21 to S44) have
been designed in silico to disrupt the formation of the RBD–ACE2 complex and to prevent the viral infection [7].
Small peptides (biological and synthetic) have been proposed as promising alternative drugs to block the SARS-CoV-2RBD and to interrupt the infection [8]. Lactoferricin B, minidefensins
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Figure 1:
SARS-CoV-2 bound to the ACE2 receptor. (a) Crystallized complex between the RBD of the SARS-CoV-2 s...